![]() ![]() IL-10 levels and the impaired bacterial clearance, indicating that disturbed PG system is the proximal cause of these phenomena. Indomethacin effectively blocked both the increased i.p. Anti–IL-10 Ab reversed the impaired bacterial clearance in G2A −/− mice. ![]() G2A −/− mice showed higher lethality, higher plasma cytokines, and an impaired bacterial clearance in response to a murine model of sepsis (cecal ligation and puncture), which were blocked by GdCl 3, an inhibitor of Kupffer cells. G2A is a GPCR abundantly expressed in immune cells. ![]()
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